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Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen exposures encoded by receptors on B cells and T cells. We analyzed immune receptor datasets from 593 individuals to develop MAchine Learning for Immunological Diagnosis, an interpretive framework to screen for multiple illnesses simultaneously or precisely test for one condition. This approach detects specific infections, autoimmune disorders, vaccine responses, and disease severity differences. Human-interpretable features of the model recapitulate known immune responses to severe acute respiratory syndromecoronavirus2, influenza, and human immunodeficiency virus, highlight antigen-specific receptors, and reveal distinct characteristics of systemic lupus erythematosus and type-1 diabetes autoreactivity. This analysis framework has broad potential for scientific and clinical interpretation of immune responses. 

Abstract. Permafrost-affected ecosystems of the Arctic–boreal zone in northwestern North America are undergoing profound transformation due to rapid climate change. NASA's Arctic Boreal Vulnerability Experiment (ABoVE) is investigating characteristics that make these ecosystems vulnerable or resilient to this change. ABoVE employs airborne synthetic aperture radar (SAR) as a powerful tool to characterize tundra, taiga, peatlands, and fens. Here, we present an annotated guide to the L-band and P-band airborne SAR data acquired during the 2017, 2018, 2019, and 2022 ABoVE airborne campaigns. We summarize the ∼80 SAR flight lines and how they fit into the ABoVE experimental design (Miller et al., 2023; https://doi.org/10.3334/ORNLDAAC/2150). The Supplement provides hyperlinks to extensive maps, tables, and every flight plan as well as individual flight lines. We illustrate the interdisciplinary nature of airborne SAR data with examples of preliminary results from ABoVE studies including boreal forest canopy structure from TomoSAR data over Delta Junction, AK, and the Boreal Ecosystem Research and Monitoring Sites (BERMS) area in northern Saskatchewan and active layer thickness and soil moisture data product validation. This paper is presented as a guide to enable interested readers to fully explore the ABoVE L- and P-band airborne SAR data (https://uavsar.jpl.nasa.gov/cgi-bin/data.pl). 

Subsurface imaging in arid regions is a well-known application of satellite Synthetic Aperture Radar (SAR). Archaeological prospection has often focused on L-band SAR sensors, given the ability of longer wavelengths to penetrate more deeply into sand. In contrast, this study demonstrates capabilities of shorter-wavelength, but higher spatial resolution, C-band and X-band SAR sensors in archaeological subsurface imaging at the site of ‘Uqdat al-Bakrah (Safah), Oman. Despite having varying parameters and acquisitions, both the X-band and C-band images analyzed were able to identify a subsurface paleo-channel that is not visible on the ground surface. This feature was first identified through Ground Penetrating Radar (GPR) survey, then recognized in the SAR imagery and further verified by test excavations. Both the GPR and the excavations reveal the base of the paleo-channel at a depth of 0.6 m–0.7 m. Hence, both X-band and C-band wavelengths are appropriate for subsurface archaeological prospection in suitable (dry silt and sand) conditions with specific acquisition parameters. Moreover, these results offer important new insights into the paleo-environmental context of ancient metal-working at ‘Uqdat al-Bakrah and demonstrate surface water flow roughly contemporary with the site’s occupation.